Urinary Tract Infection in Symptomatic Benign Prostate Enlargement: Prevalence, Bacteria profile and Antibiotic susceptibility

Abstract

The clinical morbidity of urinary tract infection on a background of surgical disease is enormous. This may include urosepsis, renal scarring and renal failure. This does not exclude the financial burden that may be incurred in the management of these cases. Therefore, determining the epidemiological pattern of this clinical condition is invaluable to medical practices in our environment. Our objective was to investigate the prevalence, bacterial profile and antibiotic susceptibility pattern of urinary tract infection in symptomatic benign prostate enlargement This was a hospital based retrospective observational study that was conducted over a period of one year. The case notes of patients that were managed for benign prostate enlargement between July 2024 and June 2025 were retrieved from medical record department of our institution. The information extracted from the case note includes age of the patients, urine microscopy, culture and sensitivity including method of urine sample collection at presentation, history of antibiotic intake and urethral catheterization prior presentation, previous history of urinary tract infection and previous history of urethral instrumentation. Patients with benign prostate enlargement with complete urine m/c/s results were recruited into the study while patients with previous history of UTI, history of antibiotic intake and on an indwelling urethral catheter at presentation were excluded from the study. Prevalence, bacterial profile and antibiotic susceptibility were determined. Out of the number of patients that were managed for symptomatic benign prostate enlargement over the period of review, a total of 46 patients fulfilled the recruitment criteria and they were recruited into the study. The age distribution of the study group showed a range of 43-88 years with mean of 62.5+/ 129sd. The period prevalence of urinary sepsis in this study was 47.8%. Six species of micro-organism were cultured and the most common was Escherichia coli (8, 36.3). Culture sensitivity pattern was done against some antibiotics. The most common sensitive antibiotics were imipenem (9, 40.9%), amikacin (8, 36.3%) Ciprofloxacillin (6, 27.2%) and Nitrofurantoin (7, 31.8%)The prevalence of urinary tract infection in BPH patients in our environment was 47.8% and the mostcommonly involved bacteria was Escherichia coli with imipenem being the most commonly sensitive antibiotic.